منابع مشابه
Biosynthesis of cephalosporin C.
The superiority of d-methionine over l-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of dl-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only dl-methionine-dl-sulfoxide and S-methyl-l-cy...
متن کاملInfluence of medium constituents on the biosynthesis of cephalosporin-C
Acremonium chrysogenum NCIM 1069 was used for the biosynthesis of cephalosporin-C (CPC) in batch mode of cultivation. The effect of different medium constituents for better yield of CPC was thoroughly investigated. From the results of the fermentation, it was found that ammonium sulphate as inorganic nitrogen source and methionine at the concentration of 0.4% are most suitable for higher yield ...
متن کاملBiosynthesis of Cephalosporin
OTT, J. L. (Eli Lilly and Co., Indianapolis, Ind.), C. W. GODZESKI, D. PAVEY, J. D. FARRAN, AND D. R. HORTON. Biosynthesis of cephalosporin C. I. Factors affecting the fermentation. Appl. Microbiol. 10:515-523. 1962.-A series of complex and synthetic media have been developed that are suitable for the production of cephalosporin C and cephalosporin N by a mutant strain of Cephalosporium (C.M.I....
متن کاملRegulation of cephalosporin biosynthesis.
The filamentous fungus Acremonium chrysogenum is the natural producer of the beta-lactam antibiotic cephalosporin C and is as such used worldwide in major biotechnical applications. Albeit its profound industrial importance, there is still a limited understanding about the molecular mechanisms regulating cephalosporin biosynthesis in this fungus. This review focuses on various regulatory levels...
متن کاملBiosynthesis of Cephalosporin C: I. Factors Affecting the Fermentation.
A series of complex and synthetic media have been developed that are suitable for the production of cephalosporin C and cephalosporin N by a mutant strain of Cephalosporium (C.M.I. 49,137). dl-Methionine increased the yield of both antibiotics, with more effect on cephalosporin N. l-Cystine had a greater enhancing effect on formation of cephalosporin C than on formation of cephalosporin N in sy...
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1962
ISSN: 0003-6919
DOI: 10.1128/am.10.4.321-325.1962